The premise of Anna In-Between is simple: Anna Sinclair, a thirty-nine-year-old editor at a big book publishing company in New York City returns to the (unnamed) Caribbean nation where she was born and raised in order to visit her parents, Beatrice and John Sinclair. While there, she learns her mother has advanced breast cancer, but refuses to go to the United States, which has better hospitals and equipment, for the operation that could save her life.